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Amphotericin B solubilized可溶性两性霉素B
 产品货号: AE437
 产品名称: Amphotericin B solubilized可溶性两性霉素B
 产品价格/规格: 25mg 150元/100mg 540元
 产品说明书: 点击查看
 更新时间: 2023-03-23
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  • Amphotericin B solubilized from Streptomyces sp


    CAS Number: 1397-89-3  C47H73NO17  MW 924.08










    ● Storage:2-8°C

    ● Specification:

    Form…………………….fine, light yellow, lyophylized powder

    Stock solution………… 2.5mg/ml(以有效含量计算) in H2O

    ● Product description:

    Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols, primarily ergosterols, of fungal and bacterial cell membranes. After binding to sterols, it forms channels in the membranes, causing small molecules to leak out. Amphotericin B is effective against fungi and yeast. Normal usage for maintenance of cell cultures is 2.5 mg/l with penicillin and streptomycin in the medium. For cultures already contaminated with yeast and fungus, it is recommended to use this product at 2-4 times the normal level (5-10 mg/l), without penicillin and streptomycin for 2-3 subcultures. Once the infection is under control, normal maintenance levels of amphotericin B should be used. Amphotericin B is not soluble in H2O but in DMSO. Amphotericin B solubilized is a colloidal suspension of Amphotericin B, using sodium deoxycholate as the solubilizing agent. The product is approximately 45% amphotericin B, 35% sodium deoxycholate; the balance being sodium phosphate and sodium chloride.

    ● Preparation instructions:

    Amphotericin B solubilized is reconstituted at the water in a 2.5 mg/ml stock solution. The solution must be filtered to sterilize by 0.22μm membrane.

    ● Storage/Stability:

    The lyophylized powder amphotericin B solubilized can be stable for 5 years under -20℃ protected from air and light. Stock solutions at 2-8 °C are stable for up to 1 month.

    ● Reference:

    1. Bolard, J., Biochim. Biophys. Acta, 864: 257-304 (1986).

    2. Venegas, B., et al., Biophys. J., 85, 2323-32 (2003).

    3. Vertut-Doi, A., et al., Biochem. Biophys. Res. Commun., 157, 692-97 (1988).

    4. Sau K., et al., J. Biol. Chem., 278, 37561-68 (2003).

    5. Perlman, D., Methods Enzymol., 58, 110-16 (1979).


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